Neigh-Lox® Advanced


No guts, no glory. Don’t let poor digestive tract health sideline your horse.

Available sizes:

  • 20-lb bucket (9.09 kg) (40-day supply for 1 horse when fed at maintenance level of 8 oz per day)
  • 8-lb bucket (3.62 kg) (16-day supply for 1 horse when fed at maintenance level of 8 oz per day)

Product Description

Why choose Neigh-Lox® Advanced?

Neigh-Lox Advanced provides a scientifically advanced blend of ingredients that work synergistically to maintain your horse’s digestive tract in peak condition. Horses with a healthy GI tract digest their feed more effectively so they absorb additional nutrients. They are less likely to suffer from digestive upsets. They perform better and feel great every day.

Neigh-Lox® Advanced supports a healthy equine GI tract, which reduces the incidence of:

  • Colonic irritation and ulcers


  • Colic and laminitis related to hindgut acidosis


  • Diarrhea


  • Gastric ulcers


  • Low immunity


  • Oxidative stress and cell membrane damage


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  • Why should I supplement my horse with GI tract aids like probiotics, prebiotics, and stomach buffers?

  • Yeasts, fermentation metabolites (prebiotics and probiotics), gastric buffers, and gastric coating agents all help maintain a healthy digestive tract in horses that are consuming high-grain diets, are under stress, are suffering from or are at risk for digestive tract disorders. These ingredients support a healthy digestive tract by maintaining optimal pH levels throughout the tract, supporting the healing of damaged tissues, sustaining healthy tissues, and nourishing beneficial bacteria. When horses’ digestive tracts are healthy they utilize their feed more efficiently, have an increased appetite, a stronger immune response, and are at less risk of digestive upsets that lead to serious colic and laminitic episodes.

  • What is Saccharomyces boulardii and how does it support a horse’s healthy digestive tract?

  • Saccharomyces boulardii is a yeast related to the more common Saccharomyces cerevisiae However, it contributes some very different and supportive functions to the horse’s GI tract. While many yeast products (such as S. cerevisiae) make claims of probiotic activities, decades of clinical research has demonstrated that supportive benefits can be realized from administration of S. boulardii, as it has been proven to convey specific nutrients to the lining of the small and large intestines. In fact, lyophilized S. boulardii is a living organism with extensively researched supportive qualities.

    Of all probiotics, S. boulardii has been the most extensively studied. It has been evaluated in dozens of randomized, placebo-controlled, clinical trials. Multiple trials have demonstrated significant improvement in subjects suffering from acute and chronic diarrhea. For most all horse managers/owners, diarrhea can be a difficult ailment to overcome. Studies indicate that S. boulardii supports conditions that improve or halt episodes of diarrhea, whether brought on by a toxin of Clostridium difficile (often a result of exposure from a clinic) or as a result of long-term antibiotic use or the ever-present scours experienced by many young foals. It is important to remember that continual administration is key to recovery and maintenance of healthy gut operations. Lyophilized S. boulardii is viable (alive) and active, but it is also short-lived in the digestive tract. So while it supports multiple immunostimulatory benefits, it does not multiply itself or reside within the tract beyond 3 to 5 days. Therefore, it should be supplemented at least daily in order to realize all the benefits of maintaining a healthy digestive tract.

    For those horses consuming higher quantities of grain, research has demonstrated that oral administration of the lyophilized yeast results in a stimulation of several brush border membrane enzymes. This supports a more complete digestion of nonstructural carbohydrate (NSC) feedstuffs—starches and sugars—in the foregut, thereby decreasing the amount of NSC that may escape to be fermented in the hindgut. Supporting increased digestibility of NSC feedstuffs can decrease the risk of hindgut acidosis and the problems it causes.

    Very recent research focuses on the mode of action by which S. boulardii supports the functionality of and healing of damaged intestinal lining and enteroluminal spaces. Researchers concluded that ingested S. boulardii secretes factors while moving through the gastrointestinal tract that are pro “motogenic.” That means it supports the movement of intestinal cells in repairing damaged cells in the gut epithelium. Therefore, horses that have or are suffering from colonic or gastric ulcers may realize quicker recovery when consuming S. boulardii.

  • What are fermentation metabolites and how do they support a horse’s healthy digestive tract?

  • Fermentation metabolites (FM) are produced from a proprietary yeast fermentation process. These FM support a healthy immune balance of the horse’s gastrointestinal system. A few of the nutritional metabolites in FM include polyphenols, nucleotides, and phytosterols.

    These metabolites have been shown in controlled research trials to support positive immune response when faced with a challenge. Additionally, FM can actually support the stimulation of the body’s innate immune response. Researchers observed significantly increased numbers of macrophages when subjects receiving FM were administered a bacterial challenge. Those subjects were able to more quickly and completely fight off invading organisms, and maintained improved health and production compared with control subjects.

    FM has been shown to support antioxidant status when fed to especially stressed or physically taxed horses. Hard-working equine athletes can suffer from poor antioxidant status when the products of high muscle and respiratory function are released into the body. Destructive compounds, including free radicals and peroxides, are produced during exercise; the polyphenols and polysterols provided in the FM disable these compounds and support muscle and respiratory recovery after exercise.

    In addition to directly supporting the horse’s own immune responses and antioxidant status, FM support the growth and activity of beneficial bacteria in the hindgut and throughout the GI tract. FM helps to maintain improved fiber digestion and a better balance of functional microbes throughout the digestive tract.

  • What is the difference between the original Neigh-Lox and Neigh-Lox Advanced?

  • The original Neigh-Lox was developed to maintain normal stomach pH thereby protecting the sensitive stomach lining from excess acid accumulation. It contains ingredients that buffer acid and coat the stomach lining. By maintaining healthy tissues in the stomach your horse’s risk of developing gastric ulcers is greatly reduced.

    Neigh-Lox Advanced combined the ingredients found in the original Neigh-Lox with a proprietary blend of fermentation solubles and Saccharomyces boulardii (a yeast). These ingredients work synergistically to support both a healthy foregut and hindgut. By maintaining a healthy gut, Neigh-Lox Advanced reduces the risk of gastric ulcers, colonic ulcers, diarrhea, and colic or laminitis resulting from hindgut imbalances. It also supports the healing of previously irritated or damaged tissue throughout the digestive tract.

  • Will Neigh-Lox Advanced cure stomach ulcers in horses?

  • Neigh-Lox Advanced contains a proprietary combination of antacids and coating agents designed to support reduced levels of excess acid associated with gastric ulcers (EGUS) in horses. Neigh-Lox Advanced is an affordable way to maintain a healthy stomach and to manage horses with mild to moderate ulceration (grades 1-3). Neigh-Lox Advanced supports a lower risk of reoccurrence in horses that have already been treated with omeprazole for gastric ulcers. Additionally, Neigh-Lox Advanced provides fermentation metabolites and S. boulardii that support the healing of damaged tissues as well as maintaining a strong immune system able to fight off outside invaders that might cause GI tract irritation.

  • Why do today’s horses have so much trouble with their digestive systems?

  • The simplest explanation for the challenges our horses’ gastrointestinal tracts face is, in a word, “man.” In the wild the horse is intended to be a nomadic browser. They are herbivores (plant eaters) that can meet their energy requirements solely from the grass leaves, stems and seeds found in the slopes, basins, and prairies of most of the continents. They not only survive but flourish on relatively low-quality forages. The horse’s cecum provides an optimum environment for billions of bacteria to ferment these structural carbohydrates and extract sufficient nutrients and calories from which the horse can reproduce, grow, escape prey at a gallop, and travel great distances in search of food, water, and mates. How then does man create problems for the horse’s GI tract? We “kill them with kindness,” in a manner of speaking.

    Once bound to wander far and reap what little nature had sown across water-starved prairies or snow-covered steppes, the horse now has practically unlimited sources of energy and nutrients thanks to man. We’ve cleared forests for their lush pasture; we’ve mixed grains in their energy-dense meals; we’ve even harvested their forages to optimize nutrition during those lean winter months and built shelters to protect them from the elements. Put together, it sounds as though we’ve done much good for the horse; however, for all our “help” we’ve created many problems. By not accounting for the naturally evolved processes that still occur in the domesticated horse’s gut we have made the horse susceptible to imbalances in pH and microbial populations, stomach ulcers, and colonic ulcers. Just because our horse’s behavior is domesticated doesn’t mean his digestive tract is.

  • What is fiber?

  • Fiber, sometimes referred to as slowly fermentable carbohydrates or structural carbohydrates, includes hemicellulose and cellulose. Hemicellulose and cellulose are found in the hard, rigid stems of plants and are also present in leaves. Fiber is responsible for the rigid, upright structure of plants. These carbs have a complex molecular structure that cannot be digested and broken down by gastric acids or enzymes in the foregut (stomach and small intestine). Instead, they are fermented in the hindgut by the resident microbes. Because of the complex structure of these carbohydrates, more time is required for the microbes to completely break them down, hence the name “slowly fermentable carbohydrates.”

  • Where do horses get most of the fiber in their diet?

  • Pasture and hay are the major sources of fiber. The slowly fermentable carbohydrates, or fiber, content increases as the pasture plants mature. In pasture, maturity can be determined by plant height and presence of a seed head. The taller the pasture, the more mature it is. When the pasture has seed heads, it is at its most mature stage. Hay cut at a later stage of maturity is more fibrous than hay cut in early stages of growth. Grasses (e.g., orchardgrass) tend to be more fibrous than legumes (e.g., alfalfa), which can be largely attributed to the different physical traits of grasses and legumes. Grasses generally have long, slender leaves that require more structural support, whereas legumes have rounder, broader leaves easily supported by the stem.

  • Why is fiber so important in my horse’s diet?

  • Diets too low in fiber can lead to serious health problems in horses. Horses receive most of their daily forage in the form of pasture and/or hay. Insufficient fiber in your horse’s diet can cause hindgut acidosis (too much acidity), gastric ulcers (due to lack of buffering from saliva production), and/or increased risk of cribbing, wood-chewing, and behavioral problems. A general guideline recommended by equine nutritionists is to feed 2% of your horse’s body weight in good quality fiber (slowly fermentable carbohydrates), with half of it being long-stemmed fiber. For a 1,000-lb horse, this is 10-20 lbs of forage per day.

  • What management practices can reduce the chance of digestive disturbances like colic from occurring in my horse?

  • Incorporating the following management techniques into your routine can greatly reduce the risk of digestive upset.

    • Reduce the amount of starch and sugar in your horse’s diet by replacing it with fats and fiber that are healthier for your horse’s hindgut.
    • When concentrates (pellets, sweet feeds, plain grains) are required to provide additional calories, feed multiple small meals of 4 lbs or less at each feeding. This will reduce the incidence of “escape” carbs entering the hindgut and causing acidosis (too much acid in the hindgut).
    • Feed good quality free-choice long-stem hay so your horse has an adequate fiber supply to support a healthy microbial population in his digestive tract.
    • Keep a consistent feeding schedule, even if that schedule is consistently inconsistent! When a horse is fed late, the sensitive bacteria in the hindgut begin to die off. If enough expire, the hindgut will become unbalanced and toxic. Late feedings stress some horses and others will bolt their meal when fed late. Both instances can lead to digestive upset.
    • Be sure your horse always has access to clean water. Horses need to consume 10 to 12 gallons of water a day when hanging out in the stall or pasture; more when exercised. Lack of water causes the food in the digestive tract to move slower and even become impacted.
    • Support the microbial population in the digestive tract by providing additional prebiotics and probiotics, especially to horses that are on high-grain diets, exercising hard, traveling frequently, or have a history of digestive upset.
  • Why is it bad to feed one or two large meals per day to my horse?

  • One example of what we do to confound our horse’s digestion process is meal-feeding. The horse’s relatively small stomach secretes acid continuously. However, the horse only secretes saliva while chewing. Saliva is highly buffered and naturally acts to counterbalance the acid produced in the stomach. This makes sense when we take into consideration that a horse is intended to be continually browsing food for up to 20 hours per day. When the horse is confined to a stall or dry-lot, and meal-fed two to three times per day, his digestive system does not alter to accommodate the eating schedule humans impose on it. In such cases the horse may not be eating for hours at a time, yet all the while his stomach continues to produce acid. In addition there is little saliva being produced that could counteract the acidic stomach because the horse is not chewing. Therefore, in between meals of hay and grain, your horse’s system works against him. The resulting buildup of acid increases the risk and occurrence of gastric ulcers.

    Nutritionists recommend feeding no more than 4 lbs of grain per meal. If your horse requires grain to maintain body condition, consider splitting the grain ration into several small meals throughout the day.

    Feeding diets high in starch and sugar:

    Another digestive malady facing many horses, in particular hard-working athletes or those that need additional calories to meet their energy requirements, is acute and/or chronic acidosis. This is a condition in which the pH (acid/base) level in the hindgut is too low or two acidic. This problem ultimately results from over-feeding of grains in the form of pellets, sweet feeds, or even plain grains such as oats. These feedstuffs are high in sugar and starch, also known as nonstructural carbohydrates or NSC. However, because the horse’s GI tract is designed to consume small bits of grains with lots of forage, the gastric enzymes produced for starch and sugar digestion are insufficient to fully, or even mostly, digest significant amounts of grains in the stomach and small intestine. Therefore, when large meals of grain-based feedstuffs are given, considerable amounts of readily fermentable starch and NSC escape digestion in the gastric/foregut region and arrive ready for rapid fermentation in the bacteria-dense hindgut segment. This can cause big problems for your horse.

    As the bacteria ferment the escaped (or pass through) NSC, a build-up of acids from fermentation cause the pH in the hindgut to drop drastically. As a result of low pH (high acid) a cascade of harmful events begins to unfold. There is a decrease in activity and numbers of fiber-digesting bacteria and an increase in acid-producing bacteria, resulting in the production of relatively strong acids such as lactic acid. These acids damage the epithelial tissue lining the walls of the cecum and colon. The damage results in a decreased absorptive functionality of the tissue, inflammation, and pain. This can lead to digestive upset and colic. At the same time the mass die off, certain bacteria release endotoxins (poisonous substances) into the horse’s system. These endotoxins can lead to decreased blood flow to the hooves and significantly increase the risk of laminitis (founder).

Recommended For

Neigh-Lox Advanced is recommended for horses of all ages that are:

  • Consuming high-grain diets and are therefore susceptible to grain overload and hindgut acidosis
  • Suffering from episodes of diarrhea
  • Convalescing after surgery or recovering from illness or injury

Neigh-Lox Advanced is recommended for horses at risk for developing colonic and/or gastric ulcers:

Due to a busy lifestyle where grazing is limited and stress levels are high

    • Performance or racehorses
    • Young horses in training
    • Horses constantly on the go

    Due to disposition

      • High-strung/excitable
      • Timid and easily stressed
      • Overly aggressive
      • Quiet worrier
      • Herd-bound

      Due to past history

        • Prone to sour attitude and indigestion
        • Treated for gastric or colonic ulcers in the past
        • Recent or ongoing treatment with NSAIDs and/or antibiotics


        Ingredients that complement each other

        Neigh-Lox Advanced contains a proprietary blend of ingredients that work synergistically to maintain healthy equine GI tract tissues by supporting proper pH levels throughout the tract, sustaining a favorable environment for beneficial bacteria, and supporting the healing of damaged or irritated tissues already present.

        Long acting gastric buffer and coating agents

        • Buffer excess gastric acid
        • Support the healing of damaged stomach tissues

        Saccharomyces boulardii (A true probiotic)

        • Supports complete digestion of starch and sugars in the foregut, therefore reducing the risk of hindgut upset and acidosis caused by simple carbohydrates escaping into the hindgut
        • Supports healing of stomach and colonic ulceration by supplying nutrients to the gastrointestinal tissues
        • Maintains normal GI tract environment, which reduces or eliminates episodes of acute and chronic diarrhea

        Proprietary yeast fermentation metabolites (Broad spectrum prebiotics)

        • Support a robust immune system
        • Support reduced inflammation and healing of damaged tissues
        • Supply polyphenol, nucleotides and polysterols, antioxidants that maintain healthy cell membranes and accelerate recovery after exercise
        • Sustain the growth and activity of beneficial bacteria throughout the GI tract

        Comparative Data Chart:

        See why Neigh-Lox Advanced is the leader in complete digestive tract support.

        Why pay more for less? Or worse yet, pay for something that isn’t addressing your horse’s needs?

        If your horse is suffering from gastric ulcers, choose long-acting Neigh-Lox original (look for the blue label).

        If your horse has a more complex set of gastric issues, choose the complete digestive tract support found in Neigh-Lox Advanced. (look for the pink label).

        Serving and Storage

        Neigh-Lox Advanced serving instructions:

        It is recommended to divide portions equally within a 24-hr period.

        1 scoop = 2 oz. Scoop included. Store in a cool, dry place.

        Young, growing horses (6-12 months): 2 to 3 scoops daily (4-6 oz).
        Feed 4 ounces at the rate of 2 scoops twice a day. Feed 6 ounces at the rate of 2 scoop three times per day. Do not exceed a total of 4 scoops (8 oz) per day.

        Yearlings (12-24 months): 4 to 6 scoops daily (8-12 oz).
        Feed 8 ounces at the rate of 2 scoops twice a day. Feed 12 ounces at the rate of 2 scoop three times per day. Do not exceed a total of 8 scoops (16 oz) per day.

        Mature Horses: 4 to 6 scoops daily (8-12 oz).
        Feed 8 ounces at the rate of 2 scoops twice a day. Feed 12 ounces at the rate of 2 scoop three times per day. Do not exceed a total of 8 scoops (16 oz) per day.

        Storage and shelf life:

        Store Neigh-Lox Advanced in a cool, dry place and keep the lid tightly closed between uses. Shelf life is 18 months from date of manufacture, when stored under suitable conditions.

        Available sizes:

        20-lb bucket (9.09 kg) (40-day supply for 1 horse when fed at maintenance level of 8 oz per day)

        8-lb bucket (3.62 kg) (16-day supply for 1 horse when fed at maintenance level of 8 oz per day)

        More Information

        For more information on your horse’s digestive tract health visit our blog and explore these titles.

        Gastric Ulcer Treatment: A Two-Step Approach

        Lowers the Incidence of Gastric Ulcers in Recreational Horses

        Research Proven Neigh-Lox ® is Suitable for All Horses, No Matter Their Age or Use

        Gastric Ulcers—Do You Need To Worry?

        Havoc in the Hindgut

        Managing Your Horse’s Bugs

        Laminitis: What’s Grain Overload Got to Do with It?

        The trouble with fructans

        Clarifying Carbohydrates Part I

        Clarifying Carbohydrates Part II

        Clarifying Carbohydrates Part III

        What is the difference between Neigh-Lox original and Neigh-Lox Advanced?

        Feeding to Ensure Digestive Tract Health

        Choosing supplements for senior horses that have trouble maintaining weight

        Dealing with arthritis in senior horses

        Choosing supplements for senior horses that have trouble maintaining weight

        Supplement tips that help keep horses healthy while traveling

        Feeding starch/sugar sensitive horses

        Feeding strategies to prevent laminitis in easy keepers

        Increasing your horse’s appetite

        Colonic ulcers in horses

        Don’t let the changing seasons catch your horse off guard.

        Prebiotics vs Probiotics: Understanding the difference

        Nutrition for Lay-Up/Convalescing Horses

        Don’t Let Poor Digestive Tract Health Sideline Your Horse

        Havoc in the Hindgut?

        Strategies to reduce colic in horses

        Nutrition’s Role in Horse Healing and Recovery

        Prebiotics can reduce inflammation in older horses

        Horse gut sounds and what they mean

        Managing the easy keeper

        Changes in Gut Microflora Could Provide Early Warning of EMS

        Ulcers and digestive tract imbalances in the off-the-track Thoroughbred

        Neigh-Lox® Advanced: What’s Inside the Bucket

        Targeted Solutions for Equine Metabolic Syndrome (EMS) and Cushing’s Disease (PPID)