Frequently asked questions about Neigh-Lox®

What is the difference between Neigh-Lox original and Neigh-Lox Advanced?

The original Neigh-Lox®, with the blue label, was developed in 1996 to address the ever-growing problem of stomach ulcers in horses. Neigh-Lox’s proprietary formula maintains normal stomach pH by buffering excess gastric acid and coating the stomach. Four ounces (2 scoops) of Neigh-Lox helps maintain normal stomach pH for 6 to 8 hours. Neigh-Lox can be offered two to three times daily to horses that are at high risk for developing ulcers due to pervious history or current lifestyle. Neigh-Lox can be used as needed during times of stress to maintain a healthy stomach. Neigh-Lox is an excellent follow-up to a course of omeprazole to support continuing recovery.

Neigh-Lox® Advanced, with the pink label, was formulated in response to growing concerns related to the poor hindgut health experienced by many modern horses. Diets rich in starch and stressful lifestyles make modern horses susceptible to gastric ulcers, colonic ulcers, hindgut acidosis, and microbial imbalances leading to colic, diarrhea, and laminitis. Neigh-Lox Advanced contains ingredients that not only buffer and coat the stomach like original Neigh-Lox, but support healing and lower levels of inflammation throughout the digestive tract. Neigh-Lox Advanced has yeast fermentation metabolites that support the reduction of pathogenic bacteria while populating the gut with beneficial bacteria. The inclusion of saccharomyces boulardii in Neigh-Lox Advanced reduces the risk of hindgut imbalances by supporting complete digestion of starches and sugars in the foregut, before they can escape into the hindgut and cause problems. Additionally, S. boulardii supplies nutrients to the gastrointestinal tissues that support the growth of healthy cells and healing of damaged tissue. Daily supplementation of four ounces (2 scoops), two to three times per day of Neigh-Lox Advanced is recommended. Continual support is the key to recovery and maintenance of a healthy digestive tract.


What causes gastric ulcers?

Gastric ulcers are caused by excessive acid accumulation in the stomach. In their natural state, horses spend up to 18 hours a day grazing. While they graze, they produce saliva that naturally buffers the acids found in the stomach. Excess acid irritates the non-glandular stomach lining that causes discomfort and can lead to lesions. This problem is common in modern horses that can’t graze continually. Horses on diets loaded with starchy concentrates (grains) are at additional risk. Increased stress levels play a significant role in the development of ulcers.

What is Neigh-Lox and how does it work?

Neigh-Lox contains buffering and coating agents that quickly neutralize excess gastric secretions and maintain normal tissue in the non-glandular portion of the stomach. Neigh-Lox promotes a normal gastric environment in much the same way the horse’s saliva does.

I want to protect my show horses during the competitive season. When should I begin adding Neigh-Lox to their diet?

We recommend starting horses on Neigh-Lox at least two weeks prior to the first show of the season. Continue offering Neigh-Lox throughout the season and for two weeks following the end of the season.

Showing is often stressful because horses must endure frequent shipping and constant environmental changes. Even if they look relaxed, they can still be physically stressed. Including Neigh-Lox at the rate of 4 oz per grain meal will reduce the risk of ulcer development. For horses with a history of ulcers, year-round supplementation is strongly suggested.

I have a couple of horses going into training. Do you recommend I start them on Neigh-Lox?

Yes, Neigh-Lox is a very appropriate supplement for horses in training. For the best results, start your horses on Neigh-Lox at the rate of 4 oz per grain meal at least two weeks prior to their first day of training and continue it for the duration of the training period.

Training is stressful because it requires an increased intensity of exercise and physical exertion. The starchy concentrate (grain) portions of the diet may need to be dramatically increased to meet additional energy demands. Additional starch in the diet increases the risk of ulcer development. Prolonged periods of stall confinement, reduced grazing, and frequent shipping are all situations in which excess gastric acid can accumulate and irritate the stomach.

I am relocating my mare and my vet told me to put her on Neigh-Lox during the move. She gets fed twice a day. What do you suggest?

Include Neigh-Lox at the rate of 4 oz per meal two weeks prior to shipping, with continued administration throughout the trip and for at least two weeks (longer if your horse is having trouble settling in) after arriving at your new stable. This will help reduce her chances of developing ulcers.

Research has shown that shipping (or trailering) even short distances causes anxiety in horses. During shipping, horses are exposed to routine and environmental changes that can be stressful. The accumulation of excess gastic acid irritates the sensitive stomach mucosa increasing the opportunity for ulcers to develop.

My vet scoped my gelding and found ulcers. She told me to start my horse on Neigh-Lox when he is done with the omeprazole treatments she prescribed. How is Neigh-lox different from omeprazole?

Omeprazole is a proton pump inhibitor, while Neigh-Lox is a gastric-acid neutralizer and coating agent. The two types of products have distinct purposes in the management of gastric ulceration. Proton pump inhibitors like omeprazole heal lesions in the stomach by “turning off” gastric acid production. Though treatment is expensive, this is often the first step taken to cure severe ulcers already present in the stomach.

Once an appropriate course of a proton pump inhibitor is concluded, a gastric-acid neutralizer and coating agent, such as Neigh-Lox, is given. Neigh-Lox can be administered as long as the horse is susceptible to gastric ulceration.

Neigh-Lox is an effective gastric-acid neutralizer combined with an ingredient that coats the stomach for long-lasting protection. The combination of buffering and coating ingredients supports a normal stomach environment that helps prevent ulcers from forming. It also supports the healing of minor ulceration. Scientifically formulated, Neigh-Lox is appropriate for horses of all ages, from foals and weanlings to mature performance horses. Neigh-Lox is less costly, safe for long-term use, and available in a pellet form that allows for ease of feeding.

When it is time to wean my foals, will Neigh-Lox reduce their chances of getting ulcers?

Yes, using Neigh-Lox will help your foal maintain a healthy stomach during weaning. We recommend you being to slowly incorporate Neigh-Lox into your foal’s diet at least 3 weeks prior to weaning. The goal is to be administering 2 oz of Neigh-Lox per grain meal before weaning begins. Continue to administer Neigh-Lox daily for at least two months post weaning, or as long as necessary depending on your management situation. Do not administer more than 8 oz per day until weanlings reach one year of age. Yearlings and adult horses can be feed up to 16 oz per day as needed.

Weaning is a stressful period for foals as they transition from a milk-based diet to one based largely on forage and grain. Environmental changes may also induce stress, as weanlings are alternated from pasture to stall confinement or from one pasture to another.

How can Neigh-Lox help horses in training?

Neigh-Lox supports a normal stomach environment, and reduces the risk of ulceration and the health problems that come with them. When a horse feels well, it eats better, trains better, races better, and shows better.

Can Neigh-Lox be given to any horse?

Yes. Horses of all ages, from foals to seniors, can be offered Neigh-Lox. Neigh-Lox is also safe for pregnant and nursing mares. For foals under 6 months of age, consult your veterinarian on administration rate.

I read recently that Neigh-Lox stops cribbing. I have a cribber, so I am interested in knowing if this is true.

In a study conducted by the University of Bristol in the United Kingdom, scientists evaluated the effectiveness of Neigh-Lox on decreasing the incidence of cribbing in foals. The trial concluded that the degree of ulceration had diminished considerably in crib-biting foals that had received Neigh-Lox and that cribbing behavior decreased.

There is also some anecdotal evidence that Neigh-Lox may reduce cribbing in an older horse if the cribbing is in response to stomach discomfort, but there is not yet any statistical research to back up this claim. Cribbing is considered to be a behavioral habit in older horses. It wouldn’t hurt to start your horse on Neigh-Lox, and it may certainly reduce the rate of cribbing by making your horse more comfortable if he has stomach irritation, but it won’t necessarily cure the problem of cribbing.

The consigner who sold my two-year-old puts all her sales horses on Neigh-Lox. Why?

Consigners want their horses to look and feel great prior to and during the sale. Including Neigh-Lox at the rate of 4 oz per grain meal will buffer excess acid and coat the stomach, warding off the ulcers that may develop during this time period. Ulcers can lead to sour attitude and other health problems, such as periodic bouts with colic.

Sales prep is a stressful time, due to an increased daily intake of concentrates and longer periods of stall confinement. Shipping, too, and attending the sale is stressful and increases a horse’s risk for developing ulcers.

How do I know if my horse has ulcers?

Horses with ulcers may develop the following symptoms: decrease in quality of performance, poor appetite, mild to severe bouts of colic, poor coat quality, and/or sour attitude or change in attitude. Some horses will show no symptoms at all. The best way to diagnose and assess the severity of an ulcer is to have your veterinarian scope your horse. Your vet can then suggest the best treatment and management regimen for your horse.

I have heard that too much aluminum is bad for horses. My horse has been on Neigh-Lox for several years and it really helps him. Should I be concerned since Neigh-Lox contains some aluminum?

No, you do not need to be concerned about the levels of aluminum found in Neigh-Lox. Studies have shown that a daily intake of 1,500 ppm of aluminum, an active ingredient in Neigh-Lox, causes no adverse side effects in horses. The maximum recommended daily dose of Neigh-Lox contains only 930 ppm.

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